Picayune Hotel Guide - Family Friendly Hotels in Picayune, Mississippi

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Picayune Family Friendly Hotels

Tonight
29 Dec - 30 Dec
Tomorrow
30 Dec - 31 Dec
This weekend
2 Jan - 4 Jan
Next weekend
9 Jan - 11 Jan

Our top choices for Picayune family-friendly hotels

Exterior
Holiday Inn Express Picayune-Stennis Space Center by IHG

Holiday Inn Express Picayune-Stennis Space Center by IHG

Holiday Inn Express Picayune-Stennis Space Center by IHG
2.5 star property
Picayune
9.0 out of 10, Wonderful, (644)
"Clean room and facility."
United States
Joshua
The price is €95
includes taxes & fees
4 Jan - 5 Jan 2026
Holiday Inn Express Picayune-Stennis Space Center by IHG
Terrace/patio
Adorable 3 bedroom attached cottage in quiet spot.

Adorable 3 bedroom attached cottage in quiet spot.

Adorable 3 bedroom attached cottage in quiet spot.
Picayune
10.0 out of 10, Exceptional, (38)
"This property was very clean and quiet. Very cute little place to stay. I would 100% stay again."
United States
Melinda M.
The price is €134
includes taxes & fees
4 Jan - 5 Jan 2026
Adorable 3 bedroom attached cottage in quiet spot.
In-room safe, desk, iron/ironing board, free WiFi
Super 8 by Wyndham Picayune

Super 8 by Wyndham Picayune

Super 8 by Wyndham Picayune
2.0 star property
Picayune
6.4 out of 10, (230)
"Dirty ,, had a big roach crawling on me while sleeping, no phone in the room, no wifi "
United States
Perla
The price is €43
includes taxes & fees
9 Jan - 10 Jan 2026
Super 8 by Wyndham Picayune
Interior
The Henry Smith House-Annex.

The Henry Smith House-Annex.

The Henry Smith House-Annex.
2.0 star property
Picayune
9.6 out of 10, Exceptional, (7)
"Lovely home; great ameneties"
United States
veronica
The price is €388
includes taxes & fees
30 Dec - 31 Dec
The Henry Smith House-Annex.
Pool
Econo Lodge Picayune

Econo Lodge Picayune

Econo Lodge Picayune
2.0 star property
Picayune
6.2 out of 10, (135)
"The staff was friendly and it was very quiet. The pool was not open and the room could really use updating."
United States
Heather
The price is €67
includes taxes & fees
28 Jan - 29 Jan 2026
Econo Lodge Picayune
Exterior
Quality Inn Slidell I-10

Quality Inn Slidell I-10

Quality Inn Slidell I-10
2.5 star property
Slidell
7.6 out of 10, Good, (284)
"Good staff nice rooms for the price "
United States
Matt
The price is €58
includes taxes & fees
5 Jan - 6 Jan 2026
Quality Inn Slidell I-10
Lobby
Ramada by Wyndham Diamondhead I-10/Gulfport

Ramada by Wyndham Diamondhead I-10/Gulfport

Ramada by Wyndham Diamondhead I-10/Gulfport
2.5 star property
Diamondhead
8.0 out of 10, Very good, (574)
"This place was like a diamond in the rough. It looks older but the rooms are nice and clean. The beds are very comfortable also. We enjoyed our stay"
United States
bobby
The price is €62
includes taxes & fees
9 Jan - 10 Jan 2026
Ramada by Wyndham Diamondhead I-10/Gulfport
Front of property – evening/night
Baymont by Wyndham Slidell

Baymont by Wyndham Slidell

Baymont by Wyndham Slidell
2.5 star property
Slidell
8.2 out of 10, Very good, (650)
"Rooms were good, staff was friendly "
United States
Carol
The price is €74
includes taxes & fees
5 Jan - 6 Jan 2026
Baymont by Wyndham Slidell
Front of property
Comfort Inn & Suites Slidell - New Orleans Area

Comfort Inn & Suites Slidell - New Orleans Area

Comfort Inn & Suites Slidell - New Orleans Area
3.0 star property
Slidell
8.6 out of 10, Excellent, (1004)
"The rooms were clean and well kept"
United States
Navin
The price is €99
includes taxes & fees
19 Jan - 20 Jan 2026
Comfort Inn & Suites Slidell - New Orleans Area
Outdoor pool
Best Western Slidell Hotel

Best Western Slidell Hotel

Best Western Slidell Hotel
2.5 star property
Slidell
8.2 out of 10, Very good, (1002)
"The stay was great"
United States
Joseph
The price is €83
includes taxes & fees
5 Jan - 6 Jan 2026
Best Western Slidell Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Picayune Hotel Reviews

Comfort Inn & Suites

Comfort Inn & Suites

10/10 Excellent
"We arrived after the check-in time, but the lady at the front desk treated us very kindly and helped us out. She even got us a pot of fresh coffee. We are going to stay with you guys every time we visit my sister... se you at Mardigra "
José Antonio 3-night trip
Posted 5 days ago
Comfort Inn & Suites

Frequently asked questions

What's Picayune like for family-friendly holidays?
The budget-friendly destination of Picayune is a good choice if you've been considering a getaway with your children. The excursions, swimming spots and golf are just some of the things that make this the perfect spot for family trips. Fly into Gulfport, MS (GPT-Gulfport - Biloxi Intl.), which is located 37 mi (59.5 km) from the city centre.
What's the best family accommodation in Picayune?
Holiday Inn Express Picayune-Stennis Space Center by IHG is a hotel with an indoor pool and free parking, and it's a top choice on Expedia for families.
When's the best time to book a family-friendly holiday in Picayune?
The hottest months are usually August and July, with an average temperature of 27°C, while the coldest months are January and December, with an average of 13°C. The rainiest months in Picayune are August, July, June and May, with each month seeing an average of 204 mm of rainfall.
What's there to see and do with your family in Picayune?
While you and your family are staying in Picayune, you may want to visit some family-friendly attractions such as M. M. Roberts Stadium, Crosby Memorial Library and Teddy Bear Museum. Make sure that you have lots of time for activities such as Carver Museum and NASA Stennis Space Center.
What's the best way for us to get around Picayune?
If you want to explore the larger area, hop on a train at Picayune Station. Picayune may not have many public transport options to choose from, so consider renting a car to explore more.