Photo by Isa

Panama City Hotel Guide. Hotels in Santa Ana, Panama City, Panama

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
19 Jul - 20 Jul
Tomorrow
20 Jul - 21 Jul
Next weekend
25 Jul - 27 Jul
In two weeks
1 Aug - 3 Aug

Filter by

Guest rating
Guest rating
Property class

Top Trending Hotels Near Santa Ana, Panama City

ART CASCO The Hotel
Welcome to CASCO, a hotel with a striking green facade and modern architecture featuring rectangular windows and a flat roof.

ART CASCO The Hotel

2.0 star property
7.0 out of 10, Good, (4)
"Excelente atención "
ART CASCO The Hotel
Hostal La Cigarra
Relax in a stylish space with seating areas for dining and socializing, surrounded by artwork and photographs.

Hostal La Cigarra

2.5 star property
7.4 out of 10, Good, (47)
"Great budget place to stay. Friendly, clean, good location. Would be happy to stay again in future."
Hostal La Cigarra
Hotel República
Enjoy the city view from this balcony with a tiled floor, comfortable seating, and lush greenery.

Hotel República

2.0 star property
6.6 out of 10, (171)
"The wifi is strong enough to use for work. "
Hotel República
w Charming 1BR in Santa Ana s Best Area
Apartment

w Charming 1BR in Santa Ana s Best Area

2.0 star property
The price is €114
includes taxes & fees
2 Aug - 3 Aug
w Charming 1BR in Santa Ana s Best Area
Room-sofa Bed Stay Rooftop Pool & Gym, A
Room, Multiple Bedrooms, Accessible, Smoking | Pool

Room-sofa Bed Stay Rooftop Pool & Gym, A

2.0 star property
Room-sofa Bed Stay Rooftop Pool & Gym, A
La Manzana by Wynwood House
Enjoy a comfortable stay in this stylish room with a large bed, armchair, and city view.

La Manzana by Wynwood House

3.5 star property
6.8 out of 10, (11)
"Great hotel. Very close to Casco viejo"
The price is €57
includes taxes & fees
3 Aug - 4 Aug
La Manzana by Wynwood House
Casco View Apartments
Luxury Apartment | Balcony

Casco View Apartments

3.0 star property
9.2 out of 10, Wonderful, (41)
"I liked the buildings quietness and modern style."
Casco View Apartments
Casa Quijano 06 By Wynwood House
Relax on the balcony with a view of the surrounding hills and enjoy the fresh air.

Casa Quijano 06 By Wynwood House

4.0 star property
9.4 out of 10, Exceptional, (3)
"The apartment itself was very nice, very spacious, clean, newer furniture. Just know it’s on the third floor and there is no elevator. I didn’t see a sign on the building so it was a bit tricky to figure out which door to go to after being dropped off by the Uber. Email communication from property with building entry code and picture of the property was helpful. There are two balconies but all you really see is the apartment immediately in front of you, and so just know people can see you if you...
The price is €112
includes taxes & fees
2 Aug - 3 Aug
Casa Quijano 06 By Wynwood House
Hotel Riazor
Two single beds with teal bedspreads and white pillows, a bedside table, and a wall-mounted telephone.

Hotel Riazor

3.0 star property
3.8 out of 10, (10)
"Rough neighborhood "
Hotel Riazor
Crowne Plaza Panama Airport by IHG
Relax by the pool surrounded by comfortable lounge chairs and umbrellas.

Crowne Plaza Panama Airport by IHG

4.0 star property
8.4 out of 10, Very good, (2155)
"Great spot for the night, close to the airport "
The price is €117
includes taxes & fees
7 Aug - 8 Aug
Crowne Plaza Panama Airport by IHG
Riande Aeropuerto Hotel & Casino
Relax by the serene pool surrounded by lush greenery and a picturesque bridge.

Riande Aeropuerto Hotel & Casino

4.0 star property
8.4 out of 10, Very good, (1883)
"The rooms were clean, the breakfast was delicious and having a bar and restaurant on the premises was bonus!"
The price is €119
includes taxes & fees
21 Jul - 22 Jul
Riande Aeropuerto Hotel & Casino
Courtyard by Marriott Panama Metromall
Enjoy a spacious room with a view of palm trees, a kitchenette, and a seating area.

Courtyard by Marriott Panama Metromall

4.0 star property
8.8 out of 10, Excellent, (1005)
"I really enjoyed my stay there. "
The price is €118
includes taxes & fees
26 Jul - 27 Jul
Courtyard by Marriott Panama Metromall
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Relax in the outdoor lounge area with a circular table and comfortable seating options.

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

5.0 star property
9.6 out of 10, Exceptional, (590)
"The staff was very friendly. "
The price is €193
includes taxes & fees
1 Aug - 2 Aug
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Arcadia Condo Suites
Enjoy a panoramic city view from the comfort of your room, featuring a seating area with sofa and armchairs.

Arcadia Condo Suites

2.5 star property
9.4 out of 10, Exceptional, (35)
"The view, The location, the convenience. "
Arcadia Condo Suites
The Westin Panama
Relax in a stylish lounge with sofas and chairs, surrounded by a panoramic city view.

The Westin Panama

4.0 star property
8.8 out of 10, Excellent, (287)
"Restaurant was under construction and food nearby was t the best but the hotel itself and staff were fantastic. "
The price is €162
includes taxes & fees
2 Aug - 3 Aug
The Westin Panama
Sheraton Grand Panama
Terrace/patio

Sheraton Grand Panama

4.0 star property
8.6 out of 10, Excellent, (904)
"A great stay. "
The price is €118
includes taxes & fees
26 Jul - 27 Jul
Sheraton Grand Panama
Aloft Panama
Experience the sleek, modern design of this hotel, featuring a striking vertical structure with a grid-patterned facade and a welcoming entrance.

Aloft Panama

3.5 star property
8.6 out of 10, Excellent, (823)
"Great location "
The price is €109
includes taxes & fees
27 Jul - 28 Jul
Aloft Panama
JW Marriott Panama
Relax in a tranquil setting surrounded by a clear pool and palm trees.

JW Marriott Panama

5.0 star property
8.8 out of 10, Excellent, (1005)
"We truly enjoyed our stay at this hotel and will be back in future! "
The price is €192
includes taxes & fees
1 Aug - 2 Aug
JW Marriott Panama
Ramada Plaza By Wyndham Panama Punta Pacífica
Relax in a serene outdoor space with a patio, seating areas, and a small pool.

Ramada Plaza By Wyndham Panama Punta Pacífica

4.0 star property
9.6 out of 10, Exceptional, (1003)
"Very nice hotel , loved everything "
The price is €99
includes taxes & fees
27 Jul - 28 Jul
Ramada Plaza By Wyndham Panama Punta Pacífica
Residence Inn by Marriott Panama City
Relax by the serene pool surrounded by a high-rise building complex with stunning views.

Residence Inn by Marriott Panama City

4.0 star property
9.0 out of 10, Wonderful, (490)
"We had an amazing stay at the residence in"
The price is €136
includes taxes & fees
26 Jul - 27 Jul
Residence Inn by Marriott Panama City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santa Ana

Find the best Santa Ana areas for the activities you enjoy most.
Casco Viejo map

Casco Viejo

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Metropolitan Cathedral of Panama or Interoceanic Canal Museum while you're exploring the area.

Bella Vista map

Bella Vista

1 out of top 10 points of interest in this area

Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina. You might spend time checking out top sights like Via Espana and Iglesia del Carmen.

El Cangrejo map

El Cangrejo

The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip.

San Francisco map

San Francisco

1 out of top 10 points of interest in this area

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

Punta Paitilla map

Punta Paitilla

Punta Paitilla is known for its abundant dining options, and you can plan a trip to Avenida Balboa and Multicentro Panama while you're in town.

Top Santa Ana Hotel Reviews

Sheraton Grand Panama

Sheraton Grand Panama

10/10 Excellent
"All good "
Martin 3-night trip
Posted 6 hours ago
Sheraton Grand Panama

Frequently asked questions

What's it like in Santa Ana?

Santa Ana is a neighbourhood that travellers like for its seafood restaurants, shopping and parks. Are you looking for Santa Ana travel tips? Make sure that you visit Cinta Costera and Avenida Balboa while you're in the neighbourhood.

Where is the best hotel for a stay in Santa Ana?

Based on Expedia customer reviews, Hotel República is the highest ranked property in Santa Ana. This hotel is a short 4-minute walk from Avenida Balboa, and it offers a rooftop terrace and free WiFi. Another top choice in the area is Hostal La Cigarra.

How many hotels can I expect to find in Santa Ana?

Expedia has 101 hotels and other accommodation options in Santa Ana to choose from, making this an ideal home base for exploring the greater Panama City area.

If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?

Yes! You'll find that most room reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If you booked a non-refundable reservation, you may still be able to cancel and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to view the best options available in Santa Ana.

What is there to do in this Panama City neighbourhood?

If you're looking forward to a day of shopping in Santa Ana, consider Avenida Central or Avenida Balboa, and pick out the perfect souvenir. A visit to Cinta Costera is also worth the trip while you're discovering the neighbourhood. Albrook Shopping Mall, Amador Theater and Museum of Contemporary Art Panama are just a few of the places to visit in and around Santa Ana. When you're sightseeing in Panama City, Mi Pueblito and Iglesia de la Merced are also worth a stop.