Photo by Mike McClain

Puxico Hotels

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
15 Dec - 16 Dec
Tomorrow
16 Dec - 17 Dec
This weekend
19 Dec - 21 Dec
Next weekend
26 Dec - 28 Dec

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Puxico hotels

Reception
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (796)
Located near North Main Street Historic District, this welcoming hotel offers an indoor pool for year-round swimming and a well-equipped fitness centre. Guests love the complimentary breakfast, free WiFi and parking. The helpful staff ensures a comfortable stay just minutes from local attractions.
"Staff was kind and provided a lot of information during check out."
United States
Shea
The price is €97
includes taxes & fees
10 Jan - 11 Jan 2026
Hampton Inn Poplar Bluff
Lobby
Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
3.0 star property
Poplar Bluff
9.2 out of 10, Wonderful, (963)
Discover peaceful stays near North Main Street Historic District. This hotel offers dual pools, free breakfast, and complimentary WiFi. After exploring nearby Margaret Harwell Art Museum, return to spacious rooms where the helpful staff ensures comfort.
"Nice room helpful staff. "
United States
Deborah
The price is €90
includes taxes & fees
20 Dec - 21 Dec
Drury Inn & Suites Poplar Bluff
Lobby lounge
Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (854)
"Very clean, great check in"
United States
Teresa
The price is €100
includes taxes & fees
4 Jan - 5 Jan 2026
Fairfield Inn & Suites by Marriott Poplar Bluff
Blackout curtains, free WiFi, bed sheets
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
2.0 star property
Poplar Bluff
7.8 out of 10, Good, (1005)
Enjoy a welcoming stay at this motel with free WiFi and parking near North Main Street Historic District. Staff receives praise for helpfulness, while convenient access to Margaret Harwell Art Museum enriches your Poplar Bluff experience.
"Love the updated rooms and the vending area."
United States
Kathi
The price is €68
includes taxes & fees
16 Dec - 17 Dec
Motel 6 Poplar Bluff, MO
Breakfast, lunch, dinner served; Italian cuisine
Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG
3.0 star property
Poplar Bluff
8.8 out of 10, Excellent, (701)
Italian cuisine awaits at Castellos restaurant in this peaceful hotel. Take a refreshing swim in the indoor pool, work out in the fitness centre, or explore nearby North Main Street Historic District. Guests love the helpful staff.
"Amazing place"
United States
Mladen
The price is €97
includes taxes & fees
21 Dec - 22 Dec
Holiday Inn Poplar Bluff by IHG
Courtyard
Bullwinkles Rustic Lodge

Bullwinkles Rustic Lodge

Bullwinkles Rustic Lodge
2.5 star property
Poplar Bluff
8.4 out of 10, Very good, (212)
"Had to "
United States
Brenda
Bullwinkles Rustic Lodge
Lobby sitting area
EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
3.0 star property
Marble Hill
9.6 out of 10, Exceptional, (83)
Surrounded by outdoor adventure, this hotel offers hiking and rafting access with thoughtful perks like free breakfast and parking. Guests praise the helpful staff who make every stay special in this quaint countryside retreat.
"Cute room, great food, fun soda fountain and friendly owners! Will return! "
United States
Leslie
EC Reed's Mercantile and Hotel
Lobby
Comfort Inn Poplar Bluff North

Comfort Inn Poplar Bluff North

Comfort Inn Poplar Bluff North
2.5 star property
Poplar Bluff
7.8 out of 10, Good, (398)
Enjoy peaceful accommodation near North Main Street Historic District with a seasonal outdoor pool and 24-hour fitness centre. Free breakfast, WiFi, and parking enhance your stay, while the helpful staff ensures comfort in clean rooms just minutes from local attractions.
"Good breakfast selection for the price and clean room. "
United States
Jared
The price is €89
includes taxes & fees
21 Dec - 22 Dec
Comfort Inn Poplar Bluff North
Breakfast area
Dexter Inn

Dexter Inn

Dexter Inn
2.5 star property
Dexter
7.0 out of 10, Good, (332)
This welcoming inn features a refreshing seasonal outdoor pool for summer relaxation. Located near The Heritage House and Keller Veteran Memorial, guests consistently praise the attentive staff. Enjoy convenient amenities and free self parking during your visit.
"Room was nice and spacious."
United States
Rebecca
The price is €66
includes taxes & fees
15 Jan - 16 Jan 2026
Dexter Inn
Breakfast, lunch, dinner served; American cuisine
Travelodge by Wyndham Dexter

Travelodge by Wyndham Dexter

Travelodge by Wyndham Dexter
2.0 star property
Dexter
7.6 out of 10, Good, (384)
Just minutes from The Heritage House and Keller Veteran Memorial, this practical hotel offers American cuisine at Penny's Diner, serving three meals daily. Business travellers appreciate the free WiFi, parking, and 24-hour assistance.
"Very nice"
United States
Dennis
The price is €96
includes taxes & fees
15 Jan - 16 Jan 2026
Travelodge by Wyndham Dexter
Reception
Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter
2.5 star property
Dexter
10.0 out of 10, Exceptional, (1)
"Staff was helpful and professional. The rooms were clean and comfortable "
United States
Michael
The price is €105
includes taxes & fees
15 Jan - 16 Jan 2026
Hampton Inn By Hilton Dexter
In-room safe, desk, free WiFi, bed sheets
Super 8 by Wyndham Poplar Bluff Missouri

Super 8 by Wyndham Poplar Bluff Missouri

Super 8 by Wyndham Poplar Bluff Missouri
2.0 star property
Poplar Bluff
6.6 out of 10, (623)
Located minutes from North Main Street Historic District, this motel offers complimentary WiFi and on-the-go breakfast daily. Free parking makes it easy to visit nearby Margaret Harwell Art Museum, while the train station is just 8 minutes away.
"The lady at the front was very nice. "
United States
Travis
The price is €55
includes taxes & fees
11 Jan - 12 Jan 2026
Super 8 by Wyndham Poplar Bluff Missouri
Desk, iron/ironing board, free WiFi, bed sheets
Econo Lodge Dexter

Econo Lodge Dexter

Econo Lodge Dexter
2.0 star property
Dexter
6.8 out of 10, (252)
This business-friendly motel offers complimentary continental breakfast, WiFi, and self parking. Located near The Heritage House and Dexter Welcome Centre Depot and Museum, guests consistently praise the exceptionally helpful staff.
"The stay was very nice. Animal friendly, staff is super nice and house keeping is very respectful. I appreciate everyone. "
United States
Michelle
The price is €57
includes taxes & fees
15 Jan - 16 Jan 2026
Econo Lodge Dexter
Desk, iron/ironing board, free WiFi, bed sheets
OYO Hickory House Inn

OYO Hickory House Inn

OYO Hickory House Inn
2.5 star property
Dexter
5.4 out of 10, (129)
This motel offers room service and free perks within easy reach of The Heritage House and Keller Veteran Memorial. Enjoy the comforts of a peaceful stay with convenient access to local attractions in Dexter.
"Nice room very comfortable bed's"
United States
Jose
The price is €48
includes taxes & fees
12 Jan - 13 Jan 2026
OYO Hickory House Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Learn more about Puxico

Head to sights like Mark Twain National Forest and Mingo Wilderness as you discover Puxico.

See all hotels in Puxico
Great place for sunrises, Bald Eagles in the winter, and Milkyway shots.
Photo by Mike McClain
Open Photo by Mike McClain

Top Puxico Hotel Reviews

Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG

10/10 Excellent
"The room was clean, comfortable, cozy. "
Deborah 1-night trip
Posted 2 days ago
Holiday Inn Poplar Bluff by IHG

More cheap stays in Puxico

Super 8 by Wyndham Poplar Bluff Missouri

Super 8 by Wyndham Poplar Bluff Missouri

2831 N Westwood Blvd Poplar Bluff MO
The price is €55 per night from 11 Jan to 12 Jan
€55
11 Jan - 12 Jan 2026
includes taxes & fees
6.4/10 (623 reviews)

Frequently asked questions

What's the best place for a stay in Puxico?
Motel 6 Poplar Bluff, MO, located 19.4 mi (31.3 km) from the heart of Puxico, is a top choice for your stay, based on our traveller data. Other good options for your trip to the area are Fairfield Inn & Suites by Marriott Poplar Bluff and Holiday Inn Poplar Bluff by IHG. See all available top hotels, or vacation rentals in Puxico.
What are some of the best holiday rentals that Puxico has to offer?
Warm, Cozy and Historic: This holiday home rental outside of Puxico offers a fireplace, a BBQ and air conditioning to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a dishwasher, a stovetop and a microwave. See all vacation rentals in Puxico.
If I need to cancel my hotel reservation in Puxico, will I receive a refund?
Yes, you'll find most hotel bookings are refundable provided that you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in Puxico.
What is staying in Puxico like?
Travellers to Puxico will find plenty to explore and enjoy. There are 54 hotels and other accommodation options in the surrounding area. Find out more about Puxico.
What is there to see in Puxico?
A couple of favourite places to visit are Mark Twain National Forest and Mingo Wilderness. You'll also find Lake Wappapello and Lake Wappapello State Park in the area. Take a look at what more there is to see and do in Expedia's Puxico guide.
What's the seasonal weather in Puxico?
The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for Puxico is 1502 mm.

Explore a world of travel with Expedia