Cheap Flights from Medellin to Panama City

View €176 flight on Mon, 1 Sep 2025Opens in a new window

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Cheap flights from Medellin to Panama City (MDE-PTY)

Prices were available within the past 7 days and start at €176 for one-way flights and €276 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Thu, 7 Aug - Sun, 10 Aug
MDE
Medellin
PTY
Panama City
€276 Return, found 1 day ago
€276
Return
found 1 day ago
Select Copa flight, departing Thu, 7 Aug from Medellin to Panama City, returning Sun, 10 Aug, priced at €276 found 1 day ago
Copa
Thu, 7 Aug - Sun, 10 Aug
MDE
Medellin
PTY
Panama City
€285 Return, found 1 day ago
€285
Return
found 1 day ago
Select Copa flight, departing Thu, 7 Aug from Medellin to Panama City, returning Sun, 10 Aug, priced at €285 found 1 day ago
Copa
Thu, 7 Aug - Sun, 10 Aug
MDE
Medellin
PTY
Panama City
€312 Return, found 1 day ago
€312
Return
found 1 day ago
Select Copa flight, departing Thu, 7 Aug from Medellin to Panama City, returning Sun, 10 Aug, priced at €312 found 1 day ago
Copa
Fri, 3 Oct - Sun, 5 Oct
MDE
Medellin
PTY
Panama City
€314 Return, found 4 days ago
€314
Return
found 4 days ago
Select Copa flight, departing Fri, 3 Oct from Medellin to Panama City, returning Sun, 5 Oct, priced at €314 found 4 days ago
Copa
Fri, 22 Aug - Thu, 28 Aug
MDE
Medellin
PTY
Panama City
€316 Return, found 1 day ago
€316
Return
found 1 day ago
Select Copa flight, departing Fri, 22 Aug from Medellin to Panama City, returning Thu, 28 Aug, priced at €316 found 1 day ago
avianca
Fri, 22 Aug - Thu, 28 Aug
MDE
Medellin
PTY
Panama City
€378 Return, found 1 day ago
€378
Return
found 1 day ago
Select avianca flight, departing Fri, 22 Aug from Medellin to Panama City, returning Thu, 28 Aug, priced at €378 found 1 day ago

Find the cheapest month to fly from Medellín (MDE) to Panama City (PTY)

March is typically the cheapest month to fly

From €175 - €321 per traveller.

Graph displaying average flight prices per month

*Available to Expedia members.