Cairo Hotels

Based on our traveller data, Quality Inn Cairo I-57 is one of the top choices for your stay. This hotel offers free breakfast and free parking. Two other choices for your stay in the area are Super 8 by Wyndham Charleston/Sikeston East MO and Quality Inn Charleston - Sikeston. See all available top hotels, or vacation rentals in Cairo.

Charming Home just minutes from Interstate and Mall: This holiday home rental outside of Cairo is equipped with a BBQ, air conditioning and laundry facilities to help you feel comfortable during your stay. Kitchen amenities include a fridge, a stovetop and a microwave. See all vacation rentals in Cairo.

Yes, the majority of room reservations are refundable if you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Cairo.

Quality Inn Cairo I-57 is a top hotel with a seasonal outdoor pool, free full breakfast and free WiFi.

Visitors can enjoy all that Cairo has to offer, including the restaurants, entertainment choices and riverfront. This city also attracts tourists with its small-town vibe. There are 24 hotels and other accommodation options in the surrounding area. Find out more about Cairo.

A couple of favourite places to visit are Mississippi River and Fort Defiance State Park. You'll also find Mound City National Cemetery and Columbus-Belmont State Park in the area. Take a look at what more there is to see and do in Expedia's Cairo guide.

The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for Cairo is 1540 mm.