Otay Mesa Holidays

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Price found within the past 48 hours. Click for updated prices.
Estancia La Jolla Hotel & Spa

Estancia La Jolla Hotel & Spa

4 out of 5
La Jolla Farms
Save 100% on your flight
per person
16 Jul - 21 Jul
found 10 hours ago
Return direct flight included
Milwaukee (MKE) to San Diego (SAN)
8.8/10 Excellent! (182 reviews)
My family and I just stayed here and had an exceptional time. We found our room was spotless, and the twin queen room worked perfectly. My daughters loved the pool and hot tub. The grounds were beautiful, and the service was top-notched. 10/10!

Reviewed on 18 Apr 2025

Alma San Diego Downtown, a Tribute Portfolio Hotel

Alma San Diego Downtown, a Tribute Portfolio Hotel

4 out of 5
Downtown San Diego
Save 100% on your flight
per person
16 Jul - 21 Jul
found 10 hours ago
Return direct flight included
Milwaukee (MKE) to San Diego (SAN)
8.8/10 Excellent! (515 reviews)
Comfortable and friendly

Reviewed on 21 Apr 2025

The Sofia Hotel

The Sofia Hotel

3.5 out of 5
Downtown San Diego
Save 100% on your flight
per person
16 Jul - 21 Jul
found 10 hours ago
Return direct flight included
Milwaukee (MKE) to San Diego (SAN)
8.2/10 Very Good! (1,442 reviews)
I love staying here it! The rooms are homie and comfortable.

Reviewed on 14 Apr 2025

The Dextro Hotel, BW Premier Collection

The Dextro Hotel, BW Premier Collection

3 out of 5
Downtown San Diego
Save 100% on your flight
per person
16 Jul - 21 Jul
found 10 hours ago
Return direct flight included
Milwaukee (MKE) to San Diego (SAN)
7/10 Good! (1,024 reviews)
Property under construction, not enough parking available for customers,

Reviewed on 20 Apr 2025

Pacific Terrace Hotel

Pacific Terrace Hotel

4 out of 5
Pacific Beach
Save 100% on your flight
per person
16 Jul - 21 Jul
found 10 hours ago
Return direct flight included
Milwaukee (MKE) to San Diego (SAN)
9.6/10 Exceptional! (1,005 reviews)
Great service and staff. Right on the beach and boardwalk. Everything conveniently around the hotel.

Reviewed on 21 Apr 2025

Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
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Downtown San Diego

2 out of top 10 points of interest in this area
4.5/5(138 area reviews)

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Find hotels in Downtown San Diego

Top hotels in Otay Mesa

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
2.5 out of 5
2485 Hotel Circle Place, San Diego, CA
The price is €107 per night from 8 May to 9 May
€107
includes taxes & fees
8 May - 9 May
7.8/10 Good! (1,502 reviews)
"Breakfast is the same every day, no variety, they close earlier that 10am for breakfast."

Reviewed on 20 Apr 2025

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
San Diego Mission Bay Resort
San Diego Mission Bay Resort
4 out of 5
1775 E Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is €230 per night from 4 May to 5 May
€230
includes taxes & fees
4 May - 5 May
8.2/10 Very Good! (1,177 reviews)
"Nice facility. Would stay there again."

Reviewed on 17 Apr 2025

San Diego Mission Bay Resort
Wyndham San Diego Bayside
Wyndham San Diego Bayside
4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is €164 per night from 7 May to 8 May
€164
includes taxes & fees
7 May - 8 May
8.2/10 Very Good! (5,674 reviews)
"Really nice"

Reviewed on 19 Apr 2025

Wyndham San Diego Bayside
See all 4,623 properties in Otay Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does an Otay Mesa holiday package cost?
Starting from as low as €759, a holiday package is your ticket to cheaper travel. Create your own Otay Mesa escape by choosing from our wide range of hotels, airfares and rental cars.
How do I get a cheap travel package to Otay Mesa?
Our Otay Mesa holiday packages mean plenty of savings for the savvy wanderer. For the best deal, simply bundle your hotel, flights and extras (such as activities) into a neat and tidy package. But impressive bargains are only the start of your next amazing adventure. When you book with Expedia, you’ll have more than 550 air carriers and 1,000,000 hotel options all over the world to pick from. No matter your budget or style, there’s a package that’s perfect for you.
Where should I stay in Otay Mesa?
A getaway to Otay Mesa wouldn’t be complete without paying a visit to North Island Credit Union Amphitheatre, Aquatica and White Water Canyon. Spend your evenings close to these tourist attractions and make sightseeing simple.
What are the top hotels in Otay Mesa?
Book a stay at Holiday Inn Express Hotel & Suites San Diego Otay Mesa, an IHG Hotel. It’s one of this neighbourhood’s most sought-after hotels. Another reputable option in Otay Mesa is Quality Suites San Diego Otay Mesa.
How far in advance should I book my Otay Mesa holiday?
Your best bet is to book early. Air carriers typically release flights around a year prior to departure, and this is an ideal opportunity to score some rock-bottom prices. Boss just told you to take your holiday time next month? That’s alright! Expedia are never short on fantastic deals to send you on the getaway of your dreams, at a price you can afford.
What does an Expedia Otay Mesa travel package include?
It comes down to what you want. If you’re travelling alone, you might decide to bundle flights and hotels. Bringing the entire family to Otay Mesa? A travel package that includes rental cars, flights and hotels might be a better fit. Expedia gives you the flexibility and freedom to tailor-make your travel package.
What should I know before booking an Otay Mesa travel package?
When you book your flights, hotels and car rentals together, you’ll land terrific discounts. Whether you’re organising an island getaway in a villa or prefer to stay in a cosy apartment in the city, Expedia can help make it happen.
Can I choose my airline with an Otay Mesa Expedia holiday package?
You can, and with over 550 airlines to select from worldwide, you have loads of choice. Look through the available options and find out which airline best suits your needs and budget.
If I'm not able to travel, can I cancel my Otay Mesa holiday package?
Don’t worry if you’re rethinking your Otay Mesa holiday package — it’s possible to change or amend your booking. And if you’ve booked it within 24 hours, you may be able to do it for free. However, bookings made more than 24 hours ago may incur fees from your hotel, airline or car rental company. We get that life can sometimes throw a spanner in the works, so make your way to our Customer Service Portal if that happens. When you’re ready to make changes, we’re ready to help.

Popular places to visit

San Diego Zoo showing a pond, landscape views and zoo animals

San Diego Zoo

4.5/5(47 reviews)

Come and see the power and beauty of nature up close at one of the biggest and best zoos in America.

San Diego Zoo
Mission Bay which includes a sandy beach

Mission Bay

4.5/5(31 reviews)

Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.

Mission Bay
Petco Park

Petco Park

4.5/5(17 reviews)

Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field.

Petco Park

Things to do

Crossing Borders: Tijuana Day Trip from San Diego

Crossing Borders: Tijuana Day Trip from San Diego

€85
per adult
100% of travellers recommend
Crossing Borders: Tijuana Day Trip from San Diego
Sesame Place® San Diego

Sesame Place® San Diego

€45
per traveller
80% of travellers recommend
Sesame Place® San Diego
Having a taste of Mexico

Intro to Mexico Walking Tour: Tijuana Day Trip from San Diego

€64
per adult
92% of travellers recommend
Intro to Mexico Walking Tour: Tijuana Day Trip from San Diego
See all activities in San Diego
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.