Otay Mesa
San Diego
Popular places to visit
San Diego Zoo
Come and see the power and beauty of nature up close at one of the biggest and best zoos in America.
San Diego Convention Center
During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's fascinating museums and entertainment choices.
Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
SeaWorld
Beautiful sea creatures, exhilarating rides and fun and educational displays – this marine park is a treat for all the family.
Balboa Park
This huge city-centre park is home to a range of fantastic cultural institutions, and it’s also a lovely place for a walk.
Mission Beach
Enjoy the old-world charm of this seaside suburb where the beautiful people live, close to central San Diego.
Things to do
Crossing Borders: Tijuana Day Trip from San Diego
Intro to Mexico Walking Tour: Tijuana Day Trip from San Diego
San Diego USS Midway with Waterfront Walking Tour
Tour from San Diego to Rosarito / Portales / Puerto Nuevo Lobster
Top hotels in Otay Mesa
Reviewed on 14 Feb 2025
Reviewed on 16 Feb 2025
Reviewed on 13 Feb 2025
Reviewed on 13 Feb 2025
Reviewed on 15 Feb 2025
Reviewed on 16 Feb 2025
Other neighbourhoods around Otay Mesa
Mid-City
While you're in Mid-City, take in top sights like Cal Coast Credit Union Open Air Theater or Viejas Arena, and hop on the metro to see more of the city at SDSU Transit Center Station or Alvarado Station.
Gaslamp Quarter
Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Harlem of the West Sites – discover Gaslamp Quarter, a destination also famous for its shopping.
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and USS Midway Museum are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
North Park
North Park is well liked for its restaurants, and you can visit sights like San Diego Zoo and Balboa Park if you have time to explore the area.
Little Italy
Visitors to Little Italy love its captivating waterfront views, and you can check out Waterfront Park and Maritime Museum of San Diego. If you want to see more in the area, you can get around town on the metro at County Center - Little Italy Station.
Hillcrest
Visitors to Hillcrest enjoy its restaurants, and if you want to do some exploring, Marston House is worth a stop.