Cheap Flights from Mexico City to Panama City

View €395 flight on Tue, 20 Jan 2026Opens in a new window

Popular airlines from Mexico City to Panama City

  • Plan, book, fly with confidence

  • trending down icon

    Be in the know

    Get alerts if flight prices drop or rise*
  • bex rewards loyalty icon

    Book smarter

    Save up to 15% on select hotels after you book a flight*
  • payments icon

    Earn twice

    Earn your airline miles on top of our rewards
    Sign in

Cheap flights from Mexico City to Panama City (MEX-PTY)

Prices were available within the past 7 days and start at €395 for one-way flights and €281 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Aeromexico
Wed, 17 Sep - Thu, 27 Nov
MEX
Mexico City
PTY
Panama City
€281 Return, found 14 hours ago
€281
Return
found 14 hours ago
Select Aeromexico flight, departing Wed, 17 Sep from Mexico City to Panama City, returning Thu, 27 Nov, priced at €281 found 14 hours ago
Copa
Mon, 21 Jul - Tue, 29 Jul
MEX
Mexico City
PTY
Panama City
€331 Return, found 6 days ago
€331
Return
found 6 days ago
Select Copa flight, departing Mon, 21 Jul from Mexico City to Panama City, returning Tue, 29 Jul, priced at €331 found 6 days ago
Copa
Wed, 17 Sep - Thu, 27 Nov
MEX
Mexico City
PTY
Panama City
€332 Return, found 14 hours ago
€332
Return
found 14 hours ago
Select Copa flight, departing Wed, 17 Sep from Mexico City to Panama City, returning Thu, 27 Nov, priced at €332 found 14 hours ago
avianca
Wed, 17 Sep - Thu, 27 Nov
MEX
Mexico City
PTY
Panama City
€553 Return, found 14 hours ago
€553
Return
found 14 hours ago
Select avianca flight, departing Wed, 17 Sep from Mexico City to Panama City, returning Thu, 27 Nov, priced at €553 found 14 hours ago
American Airlines
Tue, 20 Jan - Tue, 3 Feb
MEX
Mexico City
PTY
Panama City
€730 Return, found 4 days ago
€730
Return
found 4 days ago
Select American Airlines flight, departing Tue, 20 Jan from Mexico City to Panama City, returning Tue, 3 Feb, priced at €730 found 4 days ago
United
Wed, 17 Sep - Thu, 27 Nov
MEX
Mexico City
PTY
Panama City
€961 Return, found 14 hours ago
€961
Return
found 14 hours ago
Select United flight, departing Wed, 17 Sep from Mexico City to Panama City, returning Thu, 27 Nov, priced at €961 found 14 hours ago

Find the cheapest month to fly from Mexico City (MEX) to Panama City (PTY)

July is typically the cheapest month to fly

From €240 - €648 per traveller.

Graph displaying average flight prices per month

*Available to Expedia members.