Photo by Linda Cronan

San Antonio Hotel Guide. Hotels in Medical Center District, San Antonio, United States of America

  • Plan, book, stay with confidence

    • bex rewards loyalty icon
    Be picky
    Search almost a million properties worldwide
    payments icon
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    Sign in
    today icon
    Change your mind
    Book hotels with free cancellation

Check prices for these dates

Tonight
21 Feb - 22 Feb
Tomorrow
22 Feb - 23 Feb
This weekend
21 Feb - 23 Feb
Next weekend
28 Feb - 2 Mar

Filter by

Guest rating
Guest rating
Property class

Top Trending Hotels Near Medical Center District, San Antonio

Fairfield Inn & Suites by Marriott San Antonio Medical Center
Lobby

Fairfield Inn & Suites by Marriott San Antonio Medical Center

2.5 star property
9.0 out of 10, Wonderful, (768)
"No comment other than parking is tight and no other options are available when the location is full."
The price is €102
includes taxes & fees
23 Mar - 24 Mar
Fairfield Inn & Suites by Marriott San Antonio Medical Center
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Front of property

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

2.5 star property
8.6 out of 10, Excellent, (2257)
"As always, the stay was great."
The price is €100
includes taxes & fees
23 Feb - 24 Feb
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Drury Inn & Suites San Antonio Northwest Medical Center
Lobby

Drury Inn & Suites San Antonio Northwest Medical Center

3.0 star property
9.2 out of 10, Wonderful, (1209)
"We enjoyed the hot tub and pool. I had no idea the hotel not only has a happy hour of drinks and snacks but a full meal (chicken fajitas & hot dogs)."
The price is €113
includes taxes & fees
23 Feb - 24 Feb
Drury Inn & Suites San Antonio Northwest Medical Center
Clarion Pointe near Medical Center
Lobby

Clarion Pointe near Medical Center

2.5 star property
7.0 out of 10, Good, (1554)
"The property looks nice from the outside but the inside is a bit dated. There are random people in the hallways too. Seemed a bit odd to see a girl on her phone in the hallway for 3 hours. And another guy on the 4th floor just sitting there. Perhaps they had nowhere to go but seemed a bit odd."
The price is €47
includes taxes & fees
23 Mar - 24 Mar
Clarion Pointe near Medical Center
Park Inn by Radisson
Reception

Park Inn by Radisson

2.0 star property
7.0 out of 10, Good, (1000)
"Believe hotel is being remodeled. Room was clean but very bare. Just two chairs, and the counter with microwave and fridge. No chest, dresser, place to keep belongings off the floor. No table. Breakfast was mini oranges and packaged individual mini muffins. No frills. No extras. Clean bed. Clean room. Clean bathroom. Decent shower pressure."
The price is €73
includes taxes & fees
24 Feb - 25 Feb
Park Inn by Radisson
Atria Inn & Suites
Front of property

Atria Inn & Suites

2.0 star property
8.0 out of 10, Very good, (177)
"Excellent "
The price is €61
includes taxes & fees
24 Feb - 25 Feb
Atria Inn & Suites
Studio 6 San Antonio, Tx - Northwest Medical Center
Desk, laptop workspace, blackout curtains, free WiFi

Studio 6 San Antonio, Tx - Northwest Medical Center

2.0 star property
7.2 out of 10, Good, (117)
"Always hesitant with budget friendly motels but this one by far exceeded expectations. The staff was very friendly and the room was well equipped and VERY clean. No awkward smells or anything. Bedding was very clean and everything worked in the room (TV, refrigerator, microwave, toaster, coffee machine) Stand in shower was very clean. Great locations, close to several restaurants with a convenience store in the back of the hotel. Will stay here again."
The price is €56
includes taxes & fees
23 Feb - 24 Feb
Studio 6 San Antonio, Tx - Northwest Medical Center
OYO Inn & Suites Medical Center San Antonio
Room, 2 Queen Beds

OYO Inn & Suites Medical Center San Antonio

2.0 star property
7.2 out of 10, Good, (195)
"Nice place to stay lovely "
The price is €64
includes taxes & fees
23 Feb - 24 Feb
OYO Inn & Suites Medical Center San Antonio
Courtyard by Marriott Medical Center San Antonio
Lobby

Courtyard by Marriott Medical Center San Antonio

3.0 star property
8.6 out of 10, Excellent, (1003)
"There were some people in the hallways who were really loud, that made it difficult to get to sleep."
The price is €110
includes taxes & fees
23 Mar - 24 Mar
Courtyard by Marriott Medical Center San Antonio
SpringHill Suites by Marriott San Antonio Medical Center/NW
Premium bedding, pillow-top beds, in-room safe, desk

SpringHill Suites by Marriott San Antonio Medical Center/NW

3.0 star property
8.8 out of 10, Excellent, (1000)
"Room size was good for the price. To many homeless around the area asking for money."
The price is €117
includes taxes & fees
23 Feb - 24 Feb
SpringHill Suites by Marriott San Antonio Medical Center/NW
Country Inn & Suites by Radisson, San Antonio Medical Center, TX
Property amenity

Country Inn & Suites by Radisson, San Antonio Medical Center, TX

3.0 star property
6.6 out of 10, (1001)
"Convenient location right next to I -10. Clean and quiet. Breakfast included was a plus."
The price is €65
includes taxes & fees
27 Feb - 28 Feb
Country Inn & Suites by Radisson, San Antonio Medical Center, TX
San Antonio Marriott Northwest Medical Center
Lobby

San Antonio Marriott Northwest Medical Center

3.5 star property
8.2 out of 10, Very good, (1000)
"The room was tidy, although the restroom requires additional care. I experienced no difficulties during check-in or check-out."
The price is €112
includes taxes & fees
23 Feb - 24 Feb
San Antonio Marriott Northwest Medical Center
Motel 6 San Antonio, TX - Northwest Medical Center
Free WiFi, bed sheets

Motel 6 San Antonio, TX - Northwest Medical Center

2.0 star property
6.0 out of 10, (1000)
"Decent hotel for one night, no complaints, staff very helpful, great location for food options, best part is, $50 cash deposit at check-in and returned after quick inspection of your room at check-out! At other hotels you have to use same card you purchased room with for the deposit and then wait a month to receive the $150 deposit they charged you!"
The price is €52
includes taxes & fees
24 Feb - 25 Feb
Motel 6 San Antonio, TX - Northwest Medical Center
Studio 6 San Antonio, TX - Medical Center
Desk, laptop workspace, free WiFi, bed sheets

Studio 6 San Antonio, TX - Medical Center

2.0 star property
6.6 out of 10, (663)
"The staff was pleasant and friendly. One person behind the counter she was absolutely the best. Our room was ok and the area was ok. I’m going to complain a little about some bugs we had in the room and the very poor water pressure. Other than that it was a great place to rest our tired heads. BTW There was a faint smell of MJ in the restroom and a burn on the toilet lid that looks like they had been smoking something in there. I asked for a non smoking room."
The price is €64
includes taxes & fees
24 Feb - 25 Feb
Studio 6 San Antonio, TX - Medical Center
Flex Studios
Basic Room, Multiple Beds, Non Smoking

Flex Studios

2.5 star property
5.8 out of 10, (451)
"Very convenient location. Staff was very friendly and the room was tidy and clean. Great stay for the price."
The price is €58
includes taxes & fees
3 Mar - 4 Mar
Flex Studios
La Quinta Inn and Suites by Wyndham Schertz-San Antonio-Selma
Premium bedding, down duvets, individually decorated

La Quinta Inn and Suites by Wyndham Schertz-San Antonio-Selma

2.5 star property
8.0 out of 10, Very good, (966)
"This property put us within a mile from our intended destination. The hotel was clean, beds were comfortable and check in and out were easy. I would stay again and I would recommend. "
The price is €93
includes taxes & fees
25 Feb - 26 Feb
La Quinta Inn and Suites by Wyndham Schertz-San Antonio-Selma
Best Western Plus Atrium Inn
Property amenity

Best Western Plus Atrium Inn

2.5 star property
8.6 out of 10, Excellent, (996)
"Very clean and friendly staff."
The price is €99
includes taxes & fees
26 Feb - 27 Feb
Best Western Plus Atrium Inn
Super 8 by Wyndham Universal City
Seasonal outdoor pool

Super 8 by Wyndham Universal City

2.0 star property
6.6 out of 10, (1004)
"The bed was a bit high seem like I needed a step to get on but it was comfy."
The price is €54
includes taxes & fees
2 Mar - 3 Mar
Super 8 by Wyndham Universal City
Best Western Plus San Antonio East Inn & Suites
Spa

Best Western Plus San Antonio East Inn & Suites

2.5 star property
9.0 out of 10, Wonderful, (560)
"Staff was amazing. It’s quiet. Service was just amazing. "
The price is €120
includes taxes & fees
23 Mar - 24 Mar
Best Western Plus San Antonio East Inn & Suites
stayAPT Suites San Antonio-Randolph
Courtyard

stayAPT Suites San Antonio-Randolph

2.5 star property
8.6 out of 10, Excellent, (302)
"The assistant manager, Rachel was very nice. We had a hiccup with a credit card. I was very upset, but she fixed it. I will stay again."
The price is €109
includes taxes & fees
22 Feb - 23 Feb
stayAPT Suites San Antonio-Randolph
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Don't see what you're looking for?
See all available properties in Medical Center District
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Frequently asked questions

What is Medical Center District like?

Travellers are sure to enjoy a stay in San Antonio's Medical Center District neighbourhood. Are you looking for Medical Center District travel tips? Make sure that you visit USAA Corporate Office Headquarters and The San Antonio Art Institute while you're in the neighbourhood.

What's a favourite hotel to stay in Medical Center District?

Based on Expedia customer reviews, Drury Inn & Suites San Antonio Northwest Medical Center is the highest ranked property in Medical Center District. This hotel offers free breakfast and an indoor pool. Other favourite options in the area include Fairfield Inn & Suites by Marriott San Antonio Medical Center and Courtyard by Marriott Medical Center San Antonio.

How many hotels will I be able to find in Medical Center District?

Expedia has 130 hotels and other accommodation options in Medical Center District to choose from, making this an ideal home base for exploring the greater San Antonio area.

If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?

Yes, you'll find most hotel reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within a 24-hour period of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to review the top deals on offer in Medical Center District.

What can I see and do in this San Antonio neighbourhood?

A few attractions you might want to check out while you're in Medical Center District are USAA Corporate Office Headquarters and The San Antonio Art Institute. Wonderland of the Americas Mall and First Unitarian Universalist Church are also worth a visit when you're out sightseeing in San Antonio.