Photo by Linda Cronan

San Antonio Hotel Guide. Hotels in Medical Center District, San Antonio, United States of America

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
20 Jul - 21 Jul
Tomorrow
21 Jul - 22 Jul
Next weekend
25 Jul - 27 Jul
In two weeks
1 Aug - 3 Aug

Filter by

Guest rating
Guest rating
Property class

Top Trending Hotels Near Medical Center District, San Antonio

Fairfield Inn & Suites by Marriott San Antonio Medical Center
Relax in our spacious lobby with a comfortable seating area, coffee table, and stylish rug.

Fairfield Inn & Suites by Marriott San Antonio Medical Center

2.5 star property
9.0 out of 10, Wonderful, (924)
"Great stay"
The price is €92
includes taxes & fees
3 Aug - 4 Aug
Fairfield Inn & Suites by Marriott San Antonio Medical Center
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Experience the hotel's welcoming entrance, marked by a red awning and well-lit canopy.

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3.0 star property
8.6 out of 10, Excellent, (2760)
"Great stay "
The price is €90
includes taxes & fees
21 Jul - 22 Jul
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Atria Inn & Suites
Welcome to Atria Inn & Suites, a modern hotel with a convenient entrance.

Atria Inn & Suites

2.0 star property
7.6 out of 10, Good, (235)
"The room was bigger than I expected. Slightly dated, but clean and comfortable. It included a desk with a lamp and chair. There was a good-sized couch, coffee table, refrigerator and microwave. The AC and shower worked great. The lamp between the two beds had USB ports (very convenient) and the beds were comfortable. The staff was kind and accommodating. I checked in late and left early with no problems. Overall, I enjoyed my stay here and will likely book again in the future."
The price is €50
includes taxes & fees
21 Jul - 22 Jul
Atria Inn & Suites
Courtyard by Marriott Medical Center San Antonio
Enter a hotel with a clean, contemporary design, featuring a covered walkway leading to the main building.

Courtyard by Marriott Medical Center San Antonio

3.0 star property
8.6 out of 10, Excellent, (1007)
"Very nice place to stay."
The price is €94
includes taxes & fees
27 Jul - 28 Jul
Courtyard by Marriott Medical Center San Antonio
San Antonio Marriott Northwest Medical Center
Step into a spacious lobby with a central staircase, comfortable seating areas, and lush greenery.

San Antonio Marriott Northwest Medical Center

3.5 star property
8.4 out of 10, Very good, (1008)
"Awesome stay. "
The price is €89
includes taxes & fees
31 Jul - 1 Aug
San Antonio Marriott Northwest Medical Center
Studio 6 San Antonio, Tx - Northwest Medical Center
Two single beds with dark headboards and white bedding, a desk and chair, and a small table with chair.

Studio 6 San Antonio, Tx - Northwest Medical Center

2.0 star property
7.0 out of 10, Good, (157)
"The location was convenient and the price was very good. "
The price is €47
includes taxes & fees
29 Jul - 30 Jul
Studio 6 San Antonio, Tx - Northwest Medical Center
OYO Inn & Suites Medical Center San Antonio
Hotel features a flat facade with a covered walkway and columns.

OYO Inn & Suites Medical Center San Antonio

2.0 star property
7.2 out of 10, Good, (211)
"Beautiful place to stay love it "
The price is €70
includes taxes & fees
27 Jul - 28 Jul
OYO Inn & Suites Medical Center San Antonio
SpringHill Suites by Marriott San Antonio Medical Center/NW
Relax in a stylish room with a large bed, sofa, and abstract art.

SpringHill Suites by Marriott San Antonio Medical Center/NW

3.0 star property
8.8 out of 10, Excellent, (1002)
"Everything was nice and clean. Definitely the best stay! "
The price is €111
includes taxes & fees
21 Jul - 22 Jul
SpringHill Suites by Marriott San Antonio Medical Center/NW
Drury Inn & Suites San Antonio Northwest Medical Center
Relax in our spacious lobby with a comfortable seating area and bar counter.

Drury Inn & Suites San Antonio Northwest Medical Center

3.0 star property
9.2 out of 10, Wonderful, (1275)
"Great location and has complimentary private parking. "
The price is €102
includes taxes & fees
27 Jul - 28 Jul
Drury Inn & Suites San Antonio Northwest Medical Center
Park Inn by Radisson
Welcome to our hotel, where a modern reception area awaits with a flat-screen TV and comfortable seating.

Park Inn by Radisson

2.0 star property
7.2 out of 10, Good, (1000)
"Love it "
The price is €67
includes taxes & fees
2 Aug - 3 Aug
Park Inn by Radisson
Motel 6 San Antonio, TX - Northwest Medical Center
Two single beds with matching headboards and a desk workspace.

Motel 6 San Antonio, TX - Northwest Medical Center

2.0 star property
6.0 out of 10, (1002)
"Average "
The price is €45
includes taxes & fees
27 Jul - 28 Jul
Motel 6 San Antonio, TX - Northwest Medical Center
Flex Studios
Two single beds, a desk, and a television are featured in this hotel room.

Flex Studios

2.5 star property
6.0 out of 10, (476)
"Great central location in the medical center area, with easy and convenient highway access. "
The price is €46
includes taxes & fees
3 Aug - 4 Aug
Flex Studios
Clarion Pointe near Medical Center
Welcome to our reception area, featuring two desks with lighting and comfortable seating.

Clarion Pointe near Medical Center

2.5 star property
6.8 out of 10, (1432)
"Close to shopping areas, front staff were really friendly and room was really clean "
The price is €57
includes taxes & fees
3 Aug - 4 Aug
Clarion Pointe near Medical Center
Country Inn & Suites by Radisson, San Antonio Medical Center, TX
Enjoy cooking and serving in this well-equipped kitchen with a central island buffet station.

Country Inn & Suites by Radisson, San Antonio Medical Center, TX

3.0 star property
6.6 out of 10, (1002)
"Quick check in and great breakfast"
The price is €85
includes taxes & fees
28 Jul - 29 Jul
Country Inn & Suites by Radisson, San Antonio Medical Center, TX
Studio 6 San Antonio, TX - Medical Center
Two single beds with headboards and flat mattresses, a kitchenette with a refrigerator, coffee maker, and microwave, and a flat-screen TV for entertainment.

Studio 6 San Antonio, TX - Medical Center

2.0 star property
6.6 out of 10, (726)
"Good location for medical visit."
The price is €50
includes taxes & fees
27 Jul - 28 Jul
Studio 6 San Antonio, TX - Medical Center
La Quinta Inn and Suites by Wyndham Schertz-San Antonio-Selma
Relax in a spacious room with a large bed, functional workspace, and natural light pouring in through sheer curtains.

La Quinta Inn and Suites by Wyndham Schertz-San Antonio-Selma

3.0 star property
8.0 out of 10, Very good, (1004)
"This was a great property for a one night stay. "
The price is €86
includes taxes & fees
27 Jul - 28 Jul
La Quinta Inn and Suites by Wyndham Schertz-San Antonio-Selma
Best Western Plus Atrium Inn
Lobby

Best Western Plus Atrium Inn

2.5 star property
8.8 out of 10, Excellent, (1000)
"Great stay. "
The price is €89
includes taxes & fees
22 Jul - 23 Jul
Best Western Plus Atrium Inn
stayAPT Suites San Antonio-Randolph
Relax in this stylish seating area with a fire pit, comfortable sofa, and armchairs.

stayAPT Suites San Antonio-Randolph

2.5 star property
8.8 out of 10, Excellent, (367)
"The manager on property was great…"
stayAPT Suites San Antonio-Randolph
Best Western Garden Inn
Relax in style at our lobby, featuring a reception desk with a digital display, comfortable seating, and a warm herringbone floor.

Best Western Garden Inn

2.5 star property
8.2 out of 10, Very good, (1007)
"We enjoyed our stay here"
The price is €68
includes taxes & fees
17 Aug - 18 Aug
Best Western Garden Inn
La Quinta by Wyndham San Antonio by Frost Bank Center
La Quinta Inn & Suites features a modern architectural design with a brick and stucco exterior.

La Quinta by Wyndham San Antonio by Frost Bank Center

3.0 star property
7.8 out of 10, Good, (1001)
"Really enjoyed our stay, very clean and quiet "
The price is €80
includes taxes & fees
21 Jul - 22 Jul
La Quinta by Wyndham San Antonio by Frost Bank Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Medical Center District

Find the best Medical Center District areas for the activities you enjoy most. Learn more about Medical Center District
Learn more about Medical Center District
San Antonio River Walk showing a river or creek, a bridge and heritage architecture
Downtown San Antonio map

Downtown San Antonio

A scenic riverfront great entertainment and top sights from Alamo to Alamodome – discover Downtown San Antonio, a destination also famous for its historic sites.

Far West Side map

Far West Side

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

Uptown map

Uptown

If you're spending some time in Uptown, San Antonio Zoo and Aquarium and Marion Koogler McNay Art Museum are top sights worth seeing.

Stone Oak map

Stone Oak

Stone Oak is known for its abundant dining options, and you can plan a trip to Shops at Hardy Oak and Alta Vista while you're in town.

Northwest Side map

Northwest Side

If you're spending some time in Northwest Side, Huebner Oaks and Convocation Center are top sights worth seeing.

Top Medical Center District Hotel Reviews

Riverwalk Plaza

Riverwalk Plaza

10/10 Excellent
"Great hotel!!"
Omar 1-night trip
Posted 9 hours ago
Riverwalk Plaza

Frequently asked questions

What is Medical Center District like?

Travellers are sure to enjoy a stay in San Antonio's Medical Center District neighbourhood. Are you looking for Medical Center District travel tips? Make sure that you visit USAA Corporate Office Headquarters and Cinemark San Antonio 16 while you're in the neighbourhood.

What's a favourite hotel to stay in Medical Center District?

Based on Expedia customer reviews, Drury Inn & Suites San Antonio Northwest Medical Center is the highest ranked property in Medical Center District. This hotel offers free breakfast and an indoor pool. Other favourite options in the area include SpringHill Suites by Marriott San Antonio Medical Center/NW and Fairfield Inn & Suites by Marriott San Antonio Medical Center.

How many hotels will I be able to find in Medical Center District?

Expedia has 123 hotels and other accommodation options in Medical Center District to choose from, making this an ideal home base for exploring the greater San Antonio area.

If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?

Yes, you'll find most hotel reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within a 24-hour period of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to review the top deals on offer in Medical Center District.

What can I see and do in this San Antonio neighbourhood?

USAA Corporate Office Headquarters, Cinemark San Antonio 16 and The San Antonio Art Institute are just a few attractions to check out in Medical Center District. Wonderland of the Americas Mall and First Unitarian Universalist Church are also worth a visit when you're out sightseeing in San Antonio.