Photo by Cindy Keese

Seneca Hotel Guide - Hotels with Spa in Seneca, South Carolina

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Top Seneca Hotels with Spa

Lakeside Lodge Clemson
Aerial view

Lakeside Lodge Clemson

2.5 star property
9.0 out of 10, Wonderful, (752)
"Everything was fantastic "
The price is €127
includes taxes & fees
10 Dec - 11 Dec
Lakeside Lodge Clemson
Tru by Hilton Seneca Clemson
Terrace/patio

Tru by Hilton Seneca Clemson

2.5 star property
9.2 out of 10, Wonderful, (647)
"Staff need training "
The price is €114
includes taxes & fees
26 Dec - 27 Dec
Tru by Hilton Seneca Clemson
Quality Inn Seneca US-123
Room, 2 Double Beds, Accessible, Non Smoking

Quality Inn Seneca US-123

2.5 star property
8.0 out of 10, Very good, (553)
"Nice stay"
The price is €84
includes taxes & fees
22 Dec - 23 Dec
Quality Inn Seneca US-123
Days Inn by Wyndham Seneca / Clemson Area
Lobby

Days Inn by Wyndham Seneca / Clemson Area

2.0 star property
6.8 out of 10, (649)
"My stay was very nice. The only thing was the tv was broken in rm 121. No worries, tough, as i was busy with family "
The price is €70
includes taxes & fees
15 Dec - 16 Dec
Days Inn by Wyndham Seneca / Clemson Area
5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!
Fridge, microwave, oven, stovetop

5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!

10.0 out of 10, Exceptional, (81)
"We thoroughly enjoyed our stay in Seneca! My husband and I have 6 sons and we gather together for usually a long weekend every year. We chose Seneca for a new experience and the property was perfect for our crowd. Loved the open kitchen and huge living area. One of our sons is a gourmet cook, so he was able to be part of the family vibes as he prepped the dinner. We will probably be returning next year!!"
The price is €1,535
includes taxes & fees
4 Dec - 5 Dec
5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!
What a family lake house should be! Natural Beauty w/ space for each to enjoy!!!
Miscellaneous

What a family lake house should be! Natural Beauty w/ space for each to enjoy!!!

9.2 out of 10, Wonderful, (28)
"Overall, I highly recommend this place for anyone looking to unwind and enjoy some beautiful scenery. The house was exactly as described in the listing, which made our stay even more enjoyable. Waking up to those stunning views of the lake every morning was such a treat—it really set the perfect tone for our days. Communication with the owner was a breeze. They were super responsive and made sure we had everything we needed. Plus, the check-in and check-out process was incredibly easy, which...
What a family lake house should be! Natural Beauty w/ space for each to enjoy!!!
Best Western Seneca-Clemson
Lobby

Best Western Seneca-Clemson

2.5 star property
8.4 out of 10, Very good, (558)
"The staff made the check in and check out process very quick and easy "
The price is €88
includes taxes & fees
27 Dec - 28 Dec
Best Western Seneca-Clemson
Lakefront home w/covered dock*Pool table*Kayak/SUP*11mi to Clemson*Hot tub
Exterior

Lakefront home w/covered dock*Pool table*Kayak/SUP*11mi to Clemson*Hot tub

10.0 out of 10, Exceptional, (42)
"Loved this home. Lots of room, great area, beautiful views. "
Lakefront home w/covered dock*Pool table*Kayak/SUP*11mi to Clemson*Hot tub
Serenity Bay, Keowee Lakefront Cabin, Covered Dock, Kayaks, Clean, Near Clemson
Exterior

Serenity Bay, Keowee Lakefront Cabin, Covered Dock, Kayaks, Clean, Near Clemson

10.0 out of 10, Exceptional, (195)
"Very nice, clean, well stocked and spacious. Relatively short drive to Clemson. Great place to stay!"
Serenity Bay, Keowee Lakefront Cabin, Covered Dock, Kayaks, Clean, Near Clemson
Lakefront Lake Keowee Home with flat lawn & private dock. 14 miles to Clemson!
Exterior

Lakefront Lake Keowee Home with flat lawn & private dock. 14 miles to Clemson!

10.0 out of 10, Exceptional, (101)
"Perfect house to stay at if you are going to a Clemson game. Host was communicative and the house was adorable. We fished off the dock, roasted s’mores and watched lots of football. Would definitely rent again. "
Lakefront Lake Keowee Home with flat lawn & private dock. 14 miles to Clemson!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Looking for a spa hotel in Seneca?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Discover the lakeside setting in Seneca—worth a picture or two! Make sure you enjoy the coffee shops during your stay. Hotels with spas are the perfect way to take a break from your routine and add a layer of luxury to your weekend away.
What is the best spa hotel in Seneca?
Hampton Inn & Suites Seneca-Clemson Area, SC is a top spa hotel featuring a pool and a 24-hour fitness centre.
How many spa hotels will I find in Seneca?
Among Expedia’s 147 accommodation options in Seneca, there is 1 spa hotel.
What's there to see and do in Seneca?
Take in the sights and attractions that Seneca offers with a visit to Keowee Reservoir, Lake Keowee and Keowee Key Golf Course. If you have extra time while you’re in the area, you might want to see Lake Hartwell and Seneca City Hall.
What is a Seneca spa hotel?
Spa hotels in Seneca provide lodging and have an on-site spa offering services such as therapies as well as beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation and relaxation.