Photo by Cindy Keese

Seneca Hotel Guide - Hotels with Spa in Seneca, South Carolina

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Check availability on Seneca Hotels with Spa

Tonight
1 Aug - 2 Aug
Tomorrow
2 Aug - 3 Aug
This weekend
1 Aug - 3 Aug
Next weekend
8 Aug - 10 Aug

Top Seneca Hotels with Spa

We don't have any properties that match your exact search

Recommended hotels in Seneca

Postcard Cabins Lake Hartwell
Exterior

Postcard Cabins Lake Hartwell

2.0 star property
9.8 out of 10, Exceptional, (16)
"Clean and cute Wonderful getaway "
The price is €119
includes taxes & fees
3 Aug - 4 Aug
Postcard Cabins Lake Hartwell
Lakeside Lodge Clemson
Aerial view

Lakeside Lodge Clemson

2.5 star property
9.0 out of 10, Wonderful, (969)
"Our stay was perfect. Great outdoor area and bar staff was wonderful."
The price is €118
includes taxes & fees
3 Aug - 4 Aug
Lakeside Lodge Clemson
Fairfield Inn & Suites Seneca Clemson Univ Area
Balcony

Fairfield Inn & Suites Seneca Clemson Univ Area

2.5 star property
9.4 out of 10, Exceptional, (179)
"Liked the view of the lake and the large breakfast area. Breakfast was excellent."
The price is €124
includes taxes & fees
3 Aug - 4 Aug
Fairfield Inn & Suites Seneca Clemson Univ Area
Hampton Inn & Suites Seneca-Clemson Area
Exterior

Hampton Inn & Suites Seneca-Clemson Area

2.5 star property
9.4 out of 10, Exceptional, (618)
"Service was excellent "
The price is €117
includes taxes & fees
28 Aug - 29 Aug
Hampton Inn & Suites Seneca-Clemson Area
Quality Inn Seneca Clemson Area US-123
Free daily on-the-go breakfast

Quality Inn Seneca Clemson Area US-123

2.5 star property
8.0 out of 10, Very good, (618)
"Very nice place!"
The price is €90
includes taxes & fees
3 Aug - 4 Aug
Quality Inn Seneca Clemson Area US-123
Tru by Hilton Seneca Clemson
Lobby

Tru by Hilton Seneca Clemson

2.5 star property
9.2 out of 10, Wonderful, (749)
"Staff and property were top-notch! "
The price is €106
includes taxes & fees
31 Aug - 1 Sept
Tru by Hilton Seneca Clemson
Best Western Seneca-Clemson
Lobby

Best Western Seneca-Clemson

2.5 star property
8.4 out of 10, Very good, (598)
"The admission attendant was friendly"
The price is €94
includes taxes & fees
10 Aug - 11 Aug
Best Western Seneca-Clemson
Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!
Fridge, microwave, oven, stovetop

Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!

10.0 out of 10, Exceptional, (10)
"It was perfect for just the 2 of us!"
The price is €120
includes taxes & fees
31 Aug - 1 Sept
Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!
Days Inn by Wyndham Seneca / Clemson Area
Desk, free cots/infant beds, rollaway beds, free WiFi

Days Inn by Wyndham Seneca / Clemson Area

2.0 star property
6.8 out of 10, (690)
"The property was near the area that I needed to be in. It has ample shops and restaurants in the area "
The price is €68
includes taxes & fees
3 Aug - 4 Aug
Days Inn by Wyndham Seneca / Clemson Area
Charming 1-bedroom farmhouse in marvelous Seneca with WiFi, AC
Property grounds

Charming 1-bedroom farmhouse in marvelous Seneca with WiFi, AC

10.0 out of 10, Exceptional, (2)
"Great place and even better hosts! This place is unique and will make you never want to stay in a hotel again. "
The price is €185
includes taxes & fees
14 Aug - 15 Aug
Charming 1-bedroom farmhouse in marvelous Seneca with WiFi, AC
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Seneca Hotel Reviews

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area

10/10 Excellent
"Breakfast was very good. Staff was very polite. Nice rooms Bed covers could be a little thicker😆 Loved the pool💗"
Carmen 1-night trip
Posted 2 days ago
Hampton Inn & Suites Seneca-Clemson Area

Frequently asked questions

Looking for a spa hotel in Seneca?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Discover the lakeside setting in Seneca—worth a picture or two! Make sure you enjoy the coffee shops during your stay. Hotels with spas are the perfect way to take a break from your routine and add a layer of luxury to your weekend away.
What is the best spa hotel in Seneca?
Hampton Inn & Suites Seneca-Clemson Area, SC is a top spa hotel featuring a pool and a 24-hour fitness centre.
How many spa hotels will I find in Seneca?
Among Expedia's 147 accommodation options in Seneca, there is 1 spa hotel.
What's there to see and do in Seneca?
Take in the sights and attractions that Seneca offers with a visit to Lake Keowee, Keowee Key Golf Course and Lake Hartwell. If you have extra time while you're in the area, you might want to see Oconee County Library Seneca Branch and Keowee Reservoir.
What is a Seneca spa hotel?
Spa hotels in Seneca provide lodging and have an on-site spa offering services such as therapies as well as beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation and relaxation.