San Diego Hotel Guide. Hotels in Serra Mesa, San Diego, United States of America

  • Plan, book, stay with confidence
  • bex rewards loyalty icon
    Be picky
    Search almost a million properties worldwide
    payments icon
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    today icon
    Change your mind
    Book hotels with free cancellation

Top Trending Hotels Near Serra Mesa, San Diego

Days Inn by Wyndham San Diego Hotel Circle
3.0 star property
7.6 out of 10, Good, (1969)
"Only complaint was that there were ants in the room. Took 2 complaints to address and remedy. "
The price is €106
includes taxes & fees
1 Dec - 2 Dec
Days Inn by Wyndham San Diego Hotel Circle
Best Western Seven Seas
3.0 star property
7.6 out of 10, Good, (2593)
"Only over night but it was good, the mini fridge didn't work but they allowed me to check in a little earlier. Thank you guys"
The price is €100
includes taxes & fees
22 Dec - 23 Dec
Best Western Seven Seas
Hilton San Diego Mission Valley
4.0 star property
7.8 out of 10, Good, (1321)
"Very good location, nice breakfast option"
The price is €134
includes taxes & fees
21 Dec - 22 Dec
Hilton San Diego Mission Valley
Lafayette Hotel & Club
4.0 star property
9.2 out of 10, Wonderful, (445)
" Beautiful renovation"
The price is €213
includes taxes & fees
25 Nov - 26 Nov
Lafayette Hotel & Club
Holiday Inn Express San Diego Downtown, an IHG Hotel
2.5 star property
8.4 out of 10, Very good, (1183)
"The room was great and the hotel staff were accommodating. The hotel was also located in a great area with lots of dining surrounding."
The price is €141
includes taxes & fees
3 Dec - 4 Dec
Holiday Inn Express San Diego Downtown, an IHG Hotel
DoubleTree by Hilton Hotel San Diego - Mission Valley
4.0 star property
8.2 out of 10, Very good, (1061)
"I recently stayed at this property over the weekend and enjoyed it. The staff was friendly, property was well decorated and our rooms were clean. I would recommend this property and stay again the future when visiting San Diego. "
The price is €152
includes taxes & fees
24 Nov - 25 Nov
DoubleTree by Hilton Hotel San Diego - Mission Valley
Marriott Vacation Club®, San Diego
3.5 star property
9.2 out of 10, Wonderful, (1001)
"Can't say enough about the absolutely fantastic staff at this location. From the moment that we checked in with Jennifer and we told her that we were celebrating my sister's birthday, we were treated like VIPs. The front desk staff all personalized a birthday card for her and gave her gifts. Any time we had a question about the location of something, someone offered to show us. I've never met such friendly and accommodating staff. Kudos to all who work here. As for the room, it was spacious...
The price is €153
includes taxes & fees
11 Dec - 12 Dec
Marriott Vacation Club®, San Diego
Courtyard by Marriott San Diego Mission Valley/Hotel Circle
3.5 star property
8.2 out of 10, Very good, (1046)
"Great location "
The price is €135
includes taxes & fees
26 Nov - 27 Nov
Courtyard by Marriott San Diego Mission Valley/Hotel Circle
Uptown Inn by Vantaggio Suites
2.5 star property
8.0 out of 10, Very good, (80)
"The staff was friendly at check in. I did have a hard time getting a parking spot to check in. They said I got the code through an email but I didn't see it. The bed was not very comfortable but it was really clean. "
The price is €102
includes taxes & fees
4 Dec - 5 Dec
Uptown Inn by Vantaggio Suites
Howard Johnson by Wyndham National City/San Diego South
2.0 star property
7.2 out of 10, Good, (1006)
"It was quiet"
The price is €75
includes taxes & fees
27 Nov - 28 Nov
Howard Johnson by Wyndham National City/San Diego South
Stay Classy Hostel
2.0 star property
9.4 out of 10, Exceptional, (527)
"Fair stay for first hostel experience. Kept clean. Guest were quiet and respectful of rules. Liked the curtain that divided each room. Bathrooms easily accessible and free most of the time. Poor drainage of sinks and showers. My bed wasn’t that comfortable- had a dip in the center- might be time for new mattress. Earplug available as some guest snore throughout the night. For business trip Stay classy got the job done. rate 3.5/5. "
The price is €70
includes taxes & fees
3 Dec - 4 Dec
Stay Classy Hostel
Sheraton Mission Valley San Diego Hotel
4.0 star property
8.4 out of 10, Very good, (1216)
"Nice"
The price is €110
includes taxes & fees
28 Nov - 29 Nov
Sheraton Mission Valley San Diego Hotel
Hilton Garden Inn San Diego Mission Valley Stadium
3.0 star property
8.0 out of 10, Very good, (1000)
"Excelente "
The price is €123
includes taxes & fees
24 Nov - 25 Nov
Hilton Garden Inn San Diego Mission Valley Stadium
Lamplighter Inn & Suites at SDSU
2.5 star property
9.0 out of 10, Wonderful, (1009)
"Lovely hotel! The rooms were very clean,Breakfast was an added bonus! Staff were friendly and very helpful. Pool area beautiful. This was the third time staying here! We will be back! "
The price is €125
includes taxes & fees
5 Dec - 6 Dec
Lamplighter Inn & Suites at SDSU
San Diego Downtown Lodge
2.0 star property
6.4 out of 10, (1000)
"The rooms were very nice and clean. I liked how cool it looked inside like homie. The only thing is the view of the homeless outside but besides that it was nice. They had lots of tv channel options. Will stay here every time i come visit from now on. "
The price is €82
includes taxes & fees
25 Nov - 26 Nov
San Diego Downtown Lodge
Mission View Inn & Suites San Diego Sea World - Zoo
2.5 star property
6.0 out of 10, (428)
"We enjoyed our stay! Nice and comfortable, also felt safe "
The price is €102
includes taxes & fees
3 Dec - 4 Dec
Mission View Inn & Suites San Diego Sea World - Zoo
Studio 6 National City, CA - Naval Base San Diego
2.0 star property
7.2 out of 10, Good, (867)
"I was unaware I would be charged $12 to park our rental car. "
The price is €89
includes taxes & fees
3 Dec - 4 Dec
Studio 6 National City, CA - Naval Base San Diego
Holiday Inn Express & Suites San Diego - Mission Valley, an IHG Hotel
2.5 star property
8.8 out of 10, Excellent, (1000)
"Very clean and helpful staff. "
The price is €133
includes taxes & fees
25 Nov - 26 Nov
Holiday Inn Express & Suites San Diego - Mission Valley, an IHG Hotel
TownePlace Suites by Marriott San Diego Downtown
3.0 star property
9.0 out of 10, Wonderful, (869)
"Staying at Townplace suites was a great experience . The staff was very friendly and accommodating. I felt as if everything was either walkable or within a couple minutes with Uber or Lyft . On weekdays bar is not open that was the only downside . Other than that the room was very comfortable and nice . "
The price is €159
includes taxes & fees
1 Dec - 2 Dec
TownePlace Suites by Marriott San Diego Downtown
Baymont by Wyndham San Diego Downtown
2.5 star property
6.8 out of 10, (1004)
"Thicker blanket would have been nice. Also additional chairs would be ideal. But overall a nice place. Would stay here again in the future."
The price is €97
includes taxes & fees
25 Nov - 26 Nov
Baymont by Wyndham San Diego Downtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Don't see what you're looking for?
See all available properties in Serra Mesa
Save an average of 15% on thousands of hotels when you're signed in

Frequently asked questions

What's it like in Serra Mesa?

Guests are sure to enjoy their time checking out all that San Diego's Serra Mesa neighbourhood has to offer. Consider a visit to Stadium Golf Center & Batting Cages as part of your Serra Mesa travel plans.

Where is the best place to stay in Serra Mesa?

For your stay in Serra Mesa, Cozy 2 bedroom unit with pool is one of the top choices based on our traveller data. Other good choices for your stay in the area include Centrally Located San Diego Condo w/Hot Tub & Pool and Central location - 3br/2ba. Stay weekly. Clean, safe, quiet. .

How many hotels can I expect to find in the Serra Mesa area?

Expedia has 31 hotels and other accommodation options in Serra Mesa to choose from, making this an ideal home base for exploring the greater San Diego area.

If I need to cancel my hotel reservation in Serra Mesa, will I receive a refund?

Yes, most hotel reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to review top deals in Serra Mesa.

What can I see and do in this San Diego neighbourhood?

Stadium Golf Center & Batting Cages is an attraction you might want to check out while you're in Serra Mesa. When you're sightseeing in San Diego, Convoy District and Old Cactus Garden are also worth a stop.